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The 4-decades long effort to create an AIDS vaccine suffered a blow with news that a vaccine in a late stage trial was discontinued because results showed it to be ineffective. What are the obstacles?

NPR's Rachel Martin talks with Democratic political strategist Karen Finney about the ongoing negotiations between the White House and Congress to pass a comprehensive infrastructure bill.

Under President Biden, the Standard and Poor's 500 is set to post its best performance in the first 100 days of any president since Franklin D. Roosevelt's first term.

Trump-aligned voters are rallying around the former president in the wake of his indictment. Trump remains the frontrunner for the 2024 Republican nomination.

The historic indictment of the former president raises all sorts of legal, political and logistical questions. While it's early days, experts expect a delayed trial after Tuesday's arraignment.

After years of high rates, the country hit a new high during the pandemic, far exceeding rates in other developed nations. Black women are at especially high risk.

Republicans are looking at a crowded field to challenge President Biden for the 2024 presidential election and most will face off on a Milwaukee stage Wednesday night for the first GOP debate.

President Biden is using the G20 summit to push for a bigger, better World Bank as an alternative to China's massive lending programs, which have left some low-income countries with massive debt.

AAA is forecasting record-high travel this weekend, when more than 50 million Americans are expected to get out of town. That could mean clogged roads and snarls at airports.

Last week alone, Barack Obama outspent John McCain by about $6 million in television advertising. Jonathan Martin of Politico says there are two elements to the story: Obama's enormous fundraising advantage over McCain, and how much money the Democrat is pouring into advertising in red states.